美国密西根州立大学数学系教授 Guowei Wei博士学术讲座通知
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邀请，美国密西根州立大学数学系教授 Guowei Wei博士于6月1日来我校作学术报告。
时间：2012. 6.1（周五） 上午10:30
地点：理科楼407
报告题目：Variational multiscale models for macromolecules
Abstract: My talk focuses on a new variational multiscale paradigm for biomolecular systems. Under the physiological condition, most biological processes, such as protein folding, ion channel transport and signal transduction, occur in water, which consists of 65-90 percent of human cell mass. Therefore, it is desirable to describe membrane protein by discrete atomic and/or quantum mechanical variables; while treating the aqueous environment as a dielectric or hydrodynamic continuum. I will discuss the use of differential geometry for coupling microscopic and macroscopic scales on an equal footing. Based on the variational principle, we derive the coupled Poisson-Boltzmann, Nernst-Planck (or Kohn-Sham), Laplace-Beltrami and Navier-Stokes equations for the structure, dynamics and transport of ion-channel systems. As a consistency check, our models reproduce appropriate solvation models at equilibrium. Moreover, our model predictions are intensively validated by experimental data. Mathematical challenges include the well-posedness and numerical analysis of coupled partial differential equations (PDEs) under physical and biological constraints, lack of maximum-minimum principle, effectiveness of the multiscale approximation, and the modeling of more complex biomolecular phenomena.
报告人简介：Guowei Wei, PhD British Columbia 1996, is a professor of mathematics at Michigan State University. His research interests include many interdisciplinary areas.
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